Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
USERS' SCORE
Good
Based on 11 Reviews
8.4
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Milk Thistle Phospholipid Proprietary BlendMilk thistle extract (fruit) [providing 480 mg silymarin, 180 mg silybin, 48 mg isosilybin A and isosilybin B], phospholipids
760 mg
**
SILIPHOS® phytosome milk thistle extract (fruit) [providing 47.52 mg silybin]
160 mg
**
Top Medical Research Studies
9
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
Read More
9
Silibinin shows immunosuppressive effects
We explored the effects of silibinin, derived from silymarin (Silybum marianum), on autoimmune disorders, particularly multiple sclerosis. In a study using an animal model, we observed that silibinin notably reduced signs of spinal cord damage and inflammation, suggesting its potential immunosuppressive effects.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Read More
9
Silibinin shows promise in autoimmunity
We explored how silibinin, a compound derived from milk thistle, may influence autoimmune disorders like rheumatoid arthritis (RA).
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Read More
Most Useful Reviews
9
Effective for bile flow
29 people found this helpful
I wish to share my personal experience with this milk thistle dietary supplement. I suffer from poor bile flow, which causes pain in my right side. Upon taking Milk Thistle, relief comes swiftly, usually by the third day, and I extend my intake for 10-15 days to maintain results. My doctor recommends taking it 15-20 minutes before meals, and I've no doubt about its quality due to my repeated positive experiences. Most recently, I ordered it for my girlfriend, who struggled with liver enzyme issues post-childbirth. After taking Silymarin for two weeks, her tests returned to normal, her discomfort vanished, and her appetite improved. I experienced no side effects and highly recommend this natural remedy.
Read More
9
Improves liver cells
11 people found this helpful
This is the most effective drug for liver health! I have had liver issues for years and have explored numerous supportive remedies. Silybin, derived from the renowned milk thistle, is the most effective at enhancing hepatocyte function. This particular preparation contains a high concentration of silybin in a liposomal form for much better absorption. I take one capsule nightly during the liver's most active hours of 1-3 a.m. The product's quality is excellent, and I've had no side effects. I highly recommend it, especially when used alongside R-lipoic acid, artichoke, burdock, and dandelion for optimal liver support!
Read More
9
Highly recommended
5 people found this helpful
Having a problematic liver, I have researched many supportive drugs over the years while using iHerb. Silybin from milk thistle ranks highest for improving hepatocytes. This product delivers a substantial dose of silybin per capsule, enhanced by liposomal absorption. I take one capsule nightly as my liver functions best from 1-3 a.m. The quality is excellent, and my liver appreciates it. I recommend this, especially when combined with R-lipoic acid, artichoke, burdock, and dandelion for overall liver healing.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
- All Researches
9
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
Read More
9
Silibinin shows promise in autoimmunity
We explored how silibinin, a compound derived from milk thistle, may influence autoimmune disorders like rheumatoid arthritis (RA).
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Read More
9
We analyzed how Silymarin affects the Pdx1 gene expression and insulin production in a model of diabetes following partial pancreatic removal. With 72 rats divided into groups, those treated with Silymarin showed significant increases in both Pdx1 and insulin levels compared to untreated rats.
Notably, the treatment led to a remarkable boost in β-cell proliferation, enhancing insulin secretion and reducing blood sugar levels. These findings highlight Silymarin's potential to support the recovery of insulin-producing cells in diabetic conditions.
Notably, the treatment led to a remarkable boost in β-cell proliferation, enhancing insulin secretion and reducing blood sugar levels. These findings highlight Silymarin's potential to support the recovery of insulin-producing cells in diabetic conditions.
Read More
9
Silibinin shows immunosuppressive effects
We explored the effects of silibinin, derived from silymarin (Silybum marianum), on autoimmune disorders, particularly multiple sclerosis. In a study using an animal model, we observed that silibinin notably reduced signs of spinal cord damage and inflammation, suggesting its potential immunosuppressive effects.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Read More
8
Silymarin shows promise for MS
We explored the impact of silymarin, a compound from milk thistle, on the immune system in patients with multiple sclerosis (MS). By isolating Th1 cells from both newly diagnosed and treatment-receiving patients, we assessed how silymarin affected cell activity at various doses and times.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for bile flow
29 people found this helpful
I wish to share my personal experience with this milk thistle dietary supplement. I suffer from poor bile flow, which causes pain in my right side. Upon taking Milk Thistle, relief comes swiftly, usually by the third day, and I extend my intake for 10-15 days to maintain results. My doctor recommends taking it 15-20 minutes before meals, and I've no doubt about its quality due to my repeated positive experiences. Most recently, I ordered it for my girlfriend, who struggled with liver enzyme issues post-childbirth. After taking Silymarin for two weeks, her tests returned to normal, her discomfort vanished, and her appetite improved. I experienced no side effects and highly recommend this natural remedy.
Read More
9
Improves liver cells
11 people found this helpful
This is the most effective drug for liver health! I have had liver issues for years and have explored numerous supportive remedies. Silybin, derived from the renowned milk thistle, is the most effective at enhancing hepatocyte function. This particular preparation contains a high concentration of silybin in a liposomal form for much better absorption. I take one capsule nightly during the liver's most active hours of 1-3 a.m. The product's quality is excellent, and I've had no side effects. I highly recommend it, especially when used alongside R-lipoic acid, artichoke, burdock, and dandelion for optimal liver support!
Read More
9
Highly recommended
5 people found this helpful
Having a problematic liver, I have researched many supportive drugs over the years while using iHerb. Silybin from milk thistle ranks highest for improving hepatocytes. This product delivers a substantial dose of silybin per capsule, enhanced by liposomal absorption. I take one capsule nightly as my liver functions best from 1-3 a.m. The quality is excellent, and my liver appreciates it. I recommend this, especially when combined with R-lipoic acid, artichoke, burdock, and dandelion for overall liver healing.
Read More
9
Good detox support
1 people found this helpful
I'm ordering this for the second time, and both my husband and I find it suits us well. The quality is excellent, the tablet size is manageable, the ingredients are natural, and the taste is neutral. My liver feels rewarded with the benefits of this good detox supplement, particularly useful for bile stagnation. I plan to order this again as it is the most natural remedy for the liver.
Read More
9
Lightness regained
4 people found this helpful
After a month of taking this supplement, the heaviness in my right side has diminished, bringing me a sense of lightness. I intend to order more. Thank you!
Read More
Frequently Asked Questions
9
Effective for bile flow
29 people found this helpful
I wish to share my personal experience with this milk thistle dietary supplement. I suffer from poor bile flow, which causes pain in my right side. Upon taking Milk Thistle, relief comes swiftly, usually by the third day, and I extend my intake for 10-15 days to maintain results. My doctor recommends taking it 15-20 minutes before meals, and I've no doubt about its quality due to my repeated positive experiences. Most recently, I ordered it for my girlfriend, who struggled with liver enzyme issues post-childbirth. After taking Silymarin for two weeks, her tests returned to normal, her discomfort vanished, and her appetite improved. I experienced no side effects and highly recommend this natural remedy.
9
Lightness regained
4 people found this helpful
After a month of taking this supplement, the heaviness in my right side has diminished, bringing me a sense of lightness. I intend to order more. Thank you!
7.5
Positive effect noted
Delivery is quick and the impact is noticeable immediately after consumption. I am pleased with the results and will certainly order again next time.
8
Reduced symptoms
1 people found this helpful
I've been using Milk Thistle to support my liver health, recognising its active ingredient, silymarin, for its antioxidant and anti-inflammatory properties. I've noticed a significant reduction in symptoms linked to liver disorders, such as fatigue and indigestion. The pills are a manageable size, and I've had no adverse effects. Overall, I'm satisfied with the quality of this supplement.
7.5
Positive effects noted
1 people found this helpful
My first order from iHerb arrived promptly. I chose this product at random, and my liver responded well from the first capsule—it seemed to need this. After some time, I will provide an update on its effects, but I'm already noticing a positive response.
9
Improves liver cells
11 people found this helpful
This is the most effective drug for liver health! I have had liver issues for years and have explored numerous supportive remedies. Silybin, derived from the renowned milk thistle, is the most effective at enhancing hepatocyte function. This particular preparation contains a high concentration of silybin in a liposomal form for much better absorption. I take one capsule nightly during the liver's most active hours of 1-3 a.m. The product's quality is excellent, and I've had no side effects. I highly recommend it, especially when used alongside R-lipoic acid, artichoke, burdock, and dandelion for optimal liver support!
9
Highly recommended
5 people found this helpful
Having a problematic liver, I have researched many supportive drugs over the years while using iHerb. Silybin from milk thistle ranks highest for improving hepatocytes. This product delivers a substantial dose of silybin per capsule, enhanced by liposomal absorption. I take one capsule nightly as my liver functions best from 1-3 a.m. The quality is excellent, and my liver appreciates it. I recommend this, especially when combined with R-lipoic acid, artichoke, burdock, and dandelion for overall liver healing.
9
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
7
Potential benefits but limited studies
We investigated how silymarin and its active ingredient, silibinin, can affect symptoms of rheumatoid arthritis (RA) and osteoarthritis (OA). Using a systematic review approach, we sifted through 437 studies, finally focusing on 21 relevant ones.
Our findings revealed that these compounds show impressive properties, such as reducing inflammation and pain and protecting joint health. However, we also noted that while the experimental evidence is promising, further clinical studies are crucial to confirm these benefits and guide effective treatment strategies.
Our findings revealed that these compounds show impressive properties, such as reducing inflammation and pain and protecting joint health. However, we also noted that while the experimental evidence is promising, further clinical studies are crucial to confirm these benefits and guide effective treatment strategies.
8
In our research, we examined the effects of silymarin (Livergol®) on rheumatoid arthritis (RA) in a small group of 44 stable patients. After 90 days of treatment, we noticed a significant decrease in the Disease Activity Score (DAS-28), which assesses inflammation levels. Specifically, patients reported improvement in their symptoms, suggesting potential anti-inflammatory benefits from silymarin due to its antioxidant properties. However, the exact ways it works remain unclear, highlighting the need for more extensive studies with cytokine measurement to unravel its mechanisms further.
7
We investigated how silymarin, sourced from milk thistle, affects activated T cells, which play a role in autoimmune disorders. The study examined the impact of various silymarin doses on cell cycle progression and a key signaling pathway in these immune cells.
Our findings revealed a notable G1 cell cycle arrest after treatment with a higher silymarin dose, showing its potential to inhibit T cell proliferation without causing cell death. Additionally, silymarin significantly suppressed mTOR activity in these cells.
While the study highlights promising immunomodulatory effects, the long-term significance for autoimmune treatment remains to be fully explored.
Our findings revealed a notable G1 cell cycle arrest after treatment with a higher silymarin dose, showing its potential to inhibit T cell proliferation without causing cell death. Additionally, silymarin significantly suppressed mTOR activity in these cells.
While the study highlights promising immunomodulatory effects, the long-term significance for autoimmune treatment remains to be fully explored.
References
- Ghahfarrokhi SH, Heidari-Soureshjani S, Sherwin CMT, Azadegan-Dehkordi Z. Efficacy and Mechanisms of , Silymarin, and Silibinin on Rheumatoid Arthritis and Osteoarthritis Symptoms: A Systematic Review. Curr Rheumatol Rev. 2024;20:414. doi:10.2174/0115733971266397231122080247
- Yang HL, Shi XW. Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation. Front Neurol. 2021;12:659678. doi:10.3389/fneur.2021.659678
- Ghiasian M, Nafisi H, Ranjbar A, Mohammadi Y, Ataei S. Antioxidative effects of silymarin on the reduction of liver complications of fingolimod in patients with relapsing-remitting multiple sclerosis: A clinical trial study. J Biochem Mol Toxicol. 2021;35:e22800. doi:10.1002/jbt.22800
- Navabi F, Shaygannejad V, Abbasirad F, Vaez E, Hosseininasab F, et al. Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated from Newly Diagnosed and IFN-ß-Treated MS Patients. Inflammation. 2019;42:54. doi:10.1007/s10753-018-0872-x
- Dupuis ML, Conti F, Maselli A, Pagano MT, Ruggieri A, et al. The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis. Front Immunol. 2018;9:1903. doi:10.3389/fimmu.2018.01903
- Shavandi M, Moini A, Shakiba Y, Mashkorinia A, Dehghani M, et al. Silymarin (Livergol®) Decreases Disease Activity Score in Patients with Rheumatoid Arthritis: A Non-randomized Single-arm Clinical Trial. Iran J Allergy Asthma Immunol. 2017;16:99.
- Soto C, Raya L, Juárez J, Pérez J, González I. Effect of Silymarin in Pdx-1 expression and the proliferation of pancreatic β-cells in a pancreatectomy model. Phytomedicine. 2014;21:233. doi:10.1016/j.phymed.2013.09.008
- Gharagozloo M, Javid EN, Rezaei A, Mousavizadeh K. Silymarin inhibits cell cycle progression and mTOR activity in activated human T cells: therapeutic implications for autoimmune diseases. Basic Clin Pharmacol Toxicol. 2013;112:251. doi:10.1111/bcpt.12032
- Min K, Yoon WK, Kim SK, Kim BH. Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis. Arch Pharm Res. 2007;30:1265.
